Recent Publications

(2013 - Present)

2017

 Endothelial CaMKII as a regulator of eNOS activity and NO-mediated vasoreactivity. Murthy S, Koval OM, Ramiro Diaz JM, Kumar S, Nuno D, Scott JA, Allamargot C, Zhu LJ, Broadhurst K, Santhana V, Kutschke WJ, Irani K, Lamping KG, Grumbach IM.
PLoS One. 2017 Oct 23;12(10):e0186311. doi: 10.1371/journal.pone.0186311. eCollection 2017.
PMID: 29059213

 

 MicroRNA-204 promotes vascular endoplasmic reticulum stress and endothelial dysfunction by targeting Sirtuin1. Kassan M, Vikram A, Li Q, Kim YR, Kumar S, Gabani M, Liu J, Jacobs JS, Irani K. Sci Rep. 2017 Aug 24;7(1):9308. doi: 10.1038/s41598-017-06721-y.
PMID: 28839162

 

 Reversible lysine acetylation: another layer of post-translational regulation of the cardiac sodium channel. Yoon JY, Vikram A, London B, Irani K. Channels (Austin). 2017 Jun 9:0. doi: 10.1080/19336950.2017.1340015. [Epub ahead of print]
PMID: 28598266

 

 Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel. Vikram A, Lewarchik CM, Yoon JY, Naqvi A, Kumar S, Morgan GM, Jacobs JS, Li Q, Kim YR, Kassan M, Liu J, Gabani M, Kumar A, Mehdi H, Zhu X, Guan X, Kutschke W, Zhang X, Boudreau RL, Dai S, Matasic DS, Jung SB, Margulies KB, Kumar V, Bachschmid MM, London B, Irani K. Nat Med. 2017 Feb 13. doi: 10.1038/nm.4284. [Epub ahead of print]
PMID: 28191886
  Sirtuin1 protects endothelial Caveolin-1 expression and preserves endothelial function via suppressing miR-204 and endoplasmic reticulum stress. Kassan M, Vikram A, Kim YR, Li Q, Kassan A, Patel HH, Kumar S, Gabani M, Liu J, Jacobs JS, Irani K. Sci Rep. 2017 Feb 9;7:42265. doi: 10.1038/srep42265.
PMID: 28181559
  Sirtuin1-regulated lysine acetylation of p66Shc governs diabetes-induced vascular oxidative stress and endothelial dysfunction. Kumar S, Kim YR, Vikram A, Naqvi A, Li Q, Kassan M, Kumar V, Bachschmid MM, Jacobs JS, Kumar A, Irani K. Proc Natl Acad Sci U S A. 2017 Jan 30. pii: 201614112. doi: 10.1073/pnas.1614112114. [Epub ahead of print]
PMID: 28137876
  CR6-interacting factor 1 deficiency impairs vascular function by inhibiting the Sirt1-eNOS pathway. Nagar H, Jung S, Ryu MJ, Choi SJ, Piao S, Song HJ, Kang SK, Shin N, Kim DW, Jin SA, Jeong JO, Irani K, Jeon BH, Shong M, Kweon GR, Kim CS. Antioxid Redox Signal. 2017 Jan 24. doi: 10.1089/ars.2016.6719. [Epub ahead of print]
PMID: 28117598
  Abnormal CD161+ Immune Cells and RORΓT Mediated Enhanced IL-17F Expression in Genetic Hypertension. Singh MV, Cicha MZ, Kumar S, Meyerholz DK, Irani K, Chapleau MW, Abboud FM.
J Allergy Clin Immunol. 2017 Jan 13. pii: S0091-6749(17)30029-5. doi: 10.1016/j.jaci.2016.11.039. [Epub ahead of print]
PMID: 28093217
  Mitochondrial redox plays a critical role in the paradoxical effects of NAPDH oxidase-derived ROS on coronary endothelium. Shafique E, Torina A, Reichert K, Colantuono B, Nur N, Zeeshan K, Ravichandran V, Liu Y, Feng J, Zeeshan K, Benjamin LE, Irani K, Harrington EO, Sellke FW, Abid MR. Cardiovasc Res. 2017 Feb;113(2):234-246. doi: 10.1093/cvr/cvw249.
PMID: 28088753

2016

 P66Shc-Induced MicroRNA-34a Causes Diabetic Endothelial Dysfunction by Downregulating Sirtuin1. Li Q, Kim YR, Vikram A, Kumar S, Kassan M, Gabani M, Lee SK, Jacobs JS, Irani K. Arterioscler Thromb Vasc Biol. 2016 Dec;36(12):2394-2403.
PMID: 27789474
  Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1. Vikram A, Kim YR, Kumar S, Li Q, Kassan M, Jacobs JS, Irani K. Nat Commun. 2016 Sep 2;7:12565. doi: 10.1038/ncomms12565.
PMID: 27586459
  Essential Role of Smooth Muscle STIM1 in Hypertension and Cardiovascular Dysfunction. Kassan M, Ait-Aissa K, Radwan E, Mali V, Haddox S, Gabani M, Zhang W, Belmadani S, Irani K, Trebak M, Matrougui K. Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1900-9. doi: 10.1161/ATVBAHA.116.307869.
PMID: 27470514
  IDH2 deficiency impairs mitochondrial function in endothelial cells and endothelium-dependent vasomotor function. Park JB, Nagar H, Choi S, Jung SB, Kim HW, Kang SK, Lee JW, Lee JH, Park JW, Irani K, Jeon BH, Song HJ, Kim CS. Free Radic Biol Med. 2016 May;94:36-46. doi: 10.1016/j.freeradbiomed.2016.02.017.
PMID: 26898144

2015

 APE1/Ref-1 as a Serological Biomarker for the Detection of Bladder Cancer. Shin JH, Choi S, Lee YR, Park MS, Na YG, Irani K, Lee SD, Park JB, Kim JM, Lim JS, Jeon BH. Cancer research and treatment : official journal of Korean Cancer Association. 2015;
PMID: 25672588

2014

 Canonical Wnt signaling induces vascular endothelial dysfunction via p66Shc-regulated reactive oxygen species.  Vikram A, Kim YR, Kumar S, Naqvi A, Hoffman TA, Kumar A, Miller FJ Jr, Kim CS, Irani K.  Arteriosclerosis, thrombosis, and vascular biology. 2014; 34(10):2301-9.
PMID: 25147340
  P66Shc mediates increased platelet activation and aggregation in hypercholesterolemia. Kumar S, Vikram A, Kim YR, S Jacobs J, Irani K.  Biochemical and biophysical research communications. 2014; 449(4):496-501.
PMID: 24845561
  MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus.  Wang JM, Tao J, Chen DD, Cai JJ, Irani K, Wang Q, Yuan H, Chen AF Arteriosclerosis, thrombosis, and vascular biology. 2014; 34(1):99-109.
PMID: 24177325
  CRIF1 deficiency induces p66shc-mediated oxidative stress and endothelial activation. Nagar H, Jung SB, Kwon SK, Park JB, Shong M, Song HJ, Jeon BH, Irani K, Kim CS PloS one. 2014; 9(6):e98670.
PMID: 24906005 PMCID: PMC4048193

2013

 Histone and DNA methylation-mediated epigenetic downregulation of endothelial Kruppel-like factor 2 by low-density lipoprotein cholesterol. Kumar A, Kumar S, Vikram A, Hoffman TA, Naqvi A, Lewarchik CM, Kim YR, Irani K. Arteriosclerosis, thrombosis, and vascular biology. 2013; 33(8):1936-42.
PMID: 23723375
  Docosahexaenoic acid improves vascular function via up-regulation of SIRT1 expression in endothelial cells. Jung SB, Kwon SK, Kwon M, Nagar H, Jeon BH, Irani K, Yoon SH, Kim CS. Biochemical and biophysical research communications. 2013; 437(1):114-9.
PMID: 23806688
  Histone deacetylases inhibitor trichostatin A modulates the extracellular release of APE1/Ref-1.  Choi S, Lee YR, Park MS, Joo HK, Cho EJ, Kim HS, Kim CS, Park JB, Irani K, Jeon BH. Biochemical and biophysical research communications. 2013; 435(3):403-7.
PMID: 23665318
  Redox factor-1 activates endothelial SIRTUIN1 through reduction of conserved cysteine sulfhydryls in its deacetylase domain. Jung SB, Kim CS, Kim YR, Naqvi A, Yamamori T, Kumar S, Kumar A, Irani K. PloS one. 2013; 8(6):e65415.
PMID: 23755229

 

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