The Irani lab broadly studies molecular mechanisms regulating vascular function in health and disease. We are currently examining the role of dynamic protein lysine acetylation in the regulation of vascular endothelial function, and how microRNAs expressed in the vascular wall protect against or promote vascular disease. We are working toward identifying novel mechanisms that contribute to vascular health and disease in response to changes in the gut microbiome. We are also collaboratively looking at the role protein lysine acetylation plays in governance of cardiac electrical activity. Finally, we are interested in identifying vasospecific factors that are players in whole body energy utilization and metabolism.
Dr Irani is a member of the following programs:
- Abboud Cardiovascular Research Center
- Department of Internal Medicine - Cardiovascular Medicine
- Fraternal Order of Eagles Diabetes Research Center
- Free Radical and Radiation Biology Program
- Graduate Program in Molecular and Cellular Biology
- Pappajohn Biomedical Institute
For more information regarding positions visit or "Lab Opportunities" section.